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Neurotech Crime Files: Scientists make Bird Flu Virus in Lab

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Terror fear as scientists DELIBERATELY create 'Armageddon' bird flu virus in lab

  By Fiona Macrae

Mail Online… Last updated at 11:15 AM on 21st December 2011

A super-strain of bird flu that could infect and wipe out millions has been developed in a laboratory.

Dutch scientists who created the ‘Armageddon virus’ say it is ‘probably one of the most dangerous viruses you can make’. Their research focused on what it took to convert bird flu – which can kill more than half of those infected but does not spread easily – into a highly contagious virus.

Deadly: The new strain of bird flu could wipe out millions of people at a time. They said this knowledge would be vital for the development of vaccines and drugs to prevent a possible pandemic.

But others argue the virus should never have been created – and warn the potential if it escaped from the lab is ‘staggering’. There are also fears the recipe will be seized on by terrorists looking for a biological weapon. Ron Fouchier led a study into bird flu but he said that the work was to be used to create a vaccine.

The U.S. government is so concerned that its advisers are trying to block the details of the virus’s manufacture from being published. National Science Advisory Board for Bio-security chairman Paul Kiem, an anthrax expert, said: ‘I can’t think of another pathogenic organism that is as scary as this one. I don’t think anthrax is scary at all compared to this.’

However, others pointed out that similar fears – raised six years ago when another team of scientists recreated the Spanish flu virus that killed up to 50 million in 1918 – proved groundless. The latest controversy surrounds the H5N1 bird flu virus. In 2005, there were warnings of a potential bird flu global pandemic which would kill hundreds of millions.

Of the 573 people that have caught the bug so far worldwide, 336 have died. However, the germ’s inability to spread easily from person to person means the predicted pandemic has never materialized.

Now, scientists at the Erasmus Medical Center in Rotterdam have created a H5N1 bird flu that spreads as easily as winter flu.

Dangerous: It is feared if new details of the avian flu is published, it could be used for bio-terrorism

In experiments on ferrets – whose flu symptoms are most like humans’ – just five mutations in two key genes turned the ‘normal’ bird flu into a highly contagious, super-spreader. The scientist behind the project, Ron Fouchier, said: ‘We now know which mutations to watch for in the case of an outbreak and we can stop the outbreak before it is too late.’

A university spokesman said: ‘If this type of research is carried out under maximum safety conditions, the benefits are greater than the risks.’ But Donald Henderson, an expert in bio-security who spearheaded the worldwide drive to eradicate smallpox, told New Scientist magazine if a highly contagious virus with a 50 per cent kill rate got loose, ‘a catastrophe would result’.

Last night, the journal Science said the U.S. government’s request to publish only an abbreviated version of Dr Fouchier’s work was being taken very seriously.

 Drug Companies Accused Of Manufacturing Diseases – Again

The US Food and Drug Administration announced Wednesday that makers of estrogen-containing products that are used by women for menopause symptoms will be required to make label changes reflecting new safety concerns. In addition, women who do decide to take the drugs are being advised to take the lowest dose for the shortest possible time.

(Reuters Health) -- The announcement comes six months after a US government-sponsored study, the Women's Health Initiative (WHI), was halted three years earlier than expected. The landmark study found that women taking a hormone replacement product had a slightly higher risk of heart disease, breast cancer, stroke and blood clots compared with women not taking the hormones.

In that study, women were taking the drug Prempro, a combination of estrogen and progestin. Another arm of the WHI, in which women are taking an estrogen-only product called Premarin, is ongoing. Women who still have a uterus typically take estrogen combined with progestin, while those who have had a hysterectomy take estrogen alone.

Shortly after the WHI was halted, Wyeth Pharmaceuticals made some labeling changes and the new labeling will affect the company's estrogen-containing products--Prempro, Premphase and Premarin. The FDA is also asking all other manufacturers of estrogen or estrogen/progestin products to make similar changes as well.

" Today the FDA is taking action to provide new advice to women who use or are considering using estrogen or estrogen with progestin," said the FDA's Commissioner Dr. Mark B. McClellan.

" Now a box warning about not using estrogens for cardiovascular protection and about the findings of the WHI has been added to these products," McClellan told attendees of a press conference.

Although the FDA never approved the drugs for heart disease prevention, many doctors prescribed the drugs "off label" because there was preliminary evidence that the drugs might be helpful.

Patient information that accompanies the products will be revised to reflect the new changes.

" Different estrogens and progestins are believed to act similarly, and in the absence of data suggesting otherwise, women need to assume that the risk of other estrogens and progestins are similar," said McClellan.

A labeling guidance policy will be published shortly for the manufacturers of these drugs, according to the FDA.

Currently there are three FDA-approved indications for the use of Prempro, Premarin and Premphase. One is the treatment of hot flashes and night sweats, two common symptoms of menopause. "This indication and the FDA labeling has not changed," said McClellan.

The two other indications have been revised, said McClellan.

While the drugs are still recommended for moderate to severe vulvar and vaginal atrophy symptoms, "we now state the when prescribing for solely the treatment of symptoms of vulvar and vaginal atrophy, topical vaginal products should be considered," McClellan said.

Although HRT drugs can still be prescribed to prevent the bone-thinning disease osteoporosis. the label will say they "should only be considered for women at significant risk for osteoporosis and nonestrogen treatments should be carefully considered," he said.

There are now several different drugs on the market for patients at risk for osteoporosis, including a class of drugs called bisphosphonates.

The FDA will continue to study whether low doses of the estrogen/progestin products are safer than higher doses, and compare the safety profiles of different types of products that contain the hormones.

Above all, a woman who uses or is considering using estrogen-containing products should consult her doctor regarding the individual risks and benefits of the hormones, McClellan said.

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